Goku's one time archenemy, Piccolo is the second strongest being on the Earth, born as a concentration of Kami's negative spirits. He has powerful energy blasts, can split into two or four separate entities, and has the ability to regenerate limbs. He is often seen in a white cape. Originally from the far away planet Namek (although Piccolo doesn't know this for a long time), Piccolo starts off fighting Goku to rule the world. When the Saiyans arrive he joins forces with Goku. At first it is an uneasy alliance, but as the story unfolds, their bond becomes stronger.

While training Goku's son, Gohan for the upcoming battle against the Saiyans, Piccolo develops a special bond with Gohan. Through Gohan, the only person who has ever been a friend to him, Piccolo starts changing character for the better. He ends up sacrificing his own life to save Gohan.

While battling with Frieza, Piccolo merges with Nail, the last of the Namekain warriors and former guardian of Guru. From this merging, Piccolo gains Nail's ancient Namek fighting style, greatly enhancing Piccolo's powers and abilities.